Title : Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.

Pub. Date : 2014 Jan

PMID : 24180433






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes and is known to produce liver foci/tumors in mice and rats. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus
2 Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes and is known to produce liver foci/tumors in mice and rats. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus
3 Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes and is known to produce liver foci/tumors in mice and rats. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus
4 Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes and is known to produce liver foci/tumors in mice and rats. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus