Title : Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer.

Pub. Date : 2014 Feb 15

PMID : 24176842






3 Functional Relationships(s)
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1 Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer. Harmine prostaglandin-endoperoxide synthase 2 Homo sapiens
2 In addition, harmine significantly inhibited the expression of COX-2, PCNA, Bcl-2 and MMP-2 as well as increased Bax expression in gastric cancer cells. Harmine prostaglandin-endoperoxide synthase 2 Homo sapiens
3 These results collectively indicate that harmine induces apoptosis and inhibits proliferation, migration and invasion of human gastric cancer cells, which may be mediated by down-regulation of COX-2 expression. Harmine prostaglandin-endoperoxide synthase 2 Homo sapiens