Title : Increased permeability of microcarrier-cultured endothelial monolayers in response to histamine and thrombin. A model for the in vitro study of increased vasopermeability.

Pub. Date : 1986 Jan

PMID : 2417488






2 Functional Relationships(s)
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1 Increases in staining, as determined by the spectrophotometric quantitation of the dye after extraction from the microcarriers with formamide, occurred after treatment of human umbilical vein endothelium with histamine (10(-5) M) or thrombin (0.1 U/ml). Histamine coagulation factor II, thrombin Homo sapiens
2 Monolayer response to histamine was characterized morphologically by small openings which occurred randomly along the cell junctions; while with thrombin, the spaces, which had developed at junctions, occurred to a greater extent. Histamine coagulation factor II, thrombin Homo sapiens