Title : S(+)-ibuprofen destabilizes MYC/MYCN and AKT, increases p53 expression, and induces unfolded protein response and favorable phenotype in neuroblastoma cell lines.

Pub. Date : 2014 Jan

PMID : 24173829






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 S(+)-ibuprofen destabilizes MYC/MYCN and AKT, increases p53 expression, and induces unfolded protein response and favorable phenotype in neuroblastoma cell lines. Ibuprofen tumor protein p53 Homo sapiens
2 Gene expression profile and Ingenuity pathway analyses using TP53-mutated SKNAS cells further revealed that S(+)-ibuprofen suppressed molecular pathways associated with cell growth and conversely enhanced those of cell cycle arrest and the unfolded protein response. Ibuprofen tumor protein p53 Homo sapiens