Title : IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts.

Pub. Date : 2014 May

PMID : 24172847






2 Functional Relationships(s)
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1 Costimulation with a Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly I:C), significantly accentuated the IL-1alpha-induced inflammatory phenotype in PHLFs, and this effect was blocked with inhibitor of nuclear factor kappa-B kinase subunit beta and TGFbeta-activated kinase-1 inhibitors. Poly I-C interleukin 1 alpha Homo sapiens
2 Costimulation with a Toll-like receptor 3 ligand, polyinosinic-polycytidylic acid (poly I:C), significantly accentuated the IL-1alpha-induced inflammatory phenotype in PHLFs, and this effect was blocked with inhibitor of nuclear factor kappa-B kinase subunit beta and TGFbeta-activated kinase-1 inhibitors. Poly I-C interleukin 1 alpha Homo sapiens