Pub. Date : 2014 Feb
PMID : 24172143
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY RESULTS: The hypoxia-induced increase in COX-2 protein and mRNA levels and promoter activity were suppressed by dexamethasone, and this effect of dexamethasone was antagonized by the GR antagonist RU486. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | KEY RESULTS: The hypoxia-induced increase in COX-2 protein and mRNA levels and promoter activity were suppressed by dexamethasone, and this effect of dexamethasone was antagonized by the GR antagonist RU486. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Overexpression of GILZ in A549 cells also inhibited hypoxia-induced COX-2 expression levels and knockdown of GILZ reduced the glucocorticoid-mediated inhibition of hypoxia-induced COX-2 expression, indicating that the inhibitory effects of dexamethasone on hypoxia-induced COX-2 are mediated by GILZ. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Overexpression of GILZ in A549 cells also inhibited hypoxia-induced COX-2 expression levels and knockdown of GILZ reduced the glucocorticoid-mediated inhibition of hypoxia-induced COX-2 expression, indicating that the inhibitory effects of dexamethasone on hypoxia-induced COX-2 are mediated by GILZ. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 5 | CONCLUSION AND IMPLICATIONS: Dexamethasone-induced upregulation of GILZ not only inhibits the hypoxic-evoked induction of COX-2 expression and cell invasion but further blocks the HIF-1 pathway by destabilizing HIF-1alpha expression. | Dexamethasone | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |