Pub. Date : 2014
PMID : 24172032
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thermodynamic evaluation of the binding of bisphosphonates to human farnesyl pyrophosphate synthase. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
| 2 | BPs with nitrogen-containing side chains (N-BPs) are known to act as inhibitors for farnesyl pyrophosphate synthase (FPPS), a key enzyme in the mevalonate pathway. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
| 3 | BPs with nitrogen-containing side chains (N-BPs) are known to act as inhibitors for farnesyl pyrophosphate synthase (FPPS), a key enzyme in the mevalonate pathway. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
| 4 | In this study, we evaluated the effect of different side chains on the binding affinity of BPs to human FPPS using calorimetric techniques. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
| 5 | Differential scanning calorimetry (DSC) was used to determine the thermal unfolding of FPPS in the presence of BPs. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
| 6 | The addition of a series of clinically available BPs increased the structural stability of human FPPS by preferential binding, as indicated by an increase in the FPPS unfolding temperature. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
| 7 | The addition of a series of clinically available BPs increased the structural stability of human FPPS by preferential binding, as indicated by an increase in the FPPS unfolding temperature. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
| 8 | The magnitude of the increase was correlated with in vivo antiresorptive efficacy, suggesting that the stabilization of FPPS underlies the inhibitory effect of the BPs. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
| 9 | Isothermal titration calorimetry (ITC) experiments were performed to evaluate the binding thermodynamics of BPs against human FPPS. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |