Pub. Date : 2014 Feb
PMID : 24161444
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. | Arsenic | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
2 | In conclusion, this study demonstrates for the first time that methylated pentavalent arsenic metabolites are bifunctional inducers, as they increase CYP1A1 by activating the AhR/XRE signaling pathway and they increase NQO1 by activating the Nrf2/ARE signaling pathway in addition to the AhR/XRE pathway. | Arsenic | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |