Title : Chimeras of sperm PLCĪ¶ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization.

Pub. Date : 2013 Dec

PMID : 24152875






2 Functional Relationships(s)
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1 Notably, chimeras containing the PLCzeta XY-linker bound to PIP2-containing liposomes, while chimeras containing the PLCzeta C2 domain exhibited PI(3)P binding. Phosphatidylinositol 4,5-Diphosphate phospholipase C zeta 1 Homo sapiens
2 Our data suggest that the EF hands are not solely responsible for the nanomolar Ca(2+) sensitivity of PLCzeta and that membrane PIP2 binding involves the C2 domain and XY-linker of PLCzeta. Phosphatidylinositol 4,5-Diphosphate phospholipase C zeta 1 Homo sapiens