Title : Transport of platinum bonded nucleotides into proteoliposomes, mediated by Drosophila melanogaster thiamine pyrophosphate carrier protein (DmTpc1).

Pub. Date : 2014 Jan

PMID : 24148759






2 Functional Relationships(s)
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Protein Name
Organism
1 Although DmTpc1 has a low affinity for model [Pt(dien)(N7-5"-dGTP)] and cis-[Pt(NH3)2(py)(N7-5"-dGTP)] compared to dATP it"s well known that DNA platination level of few metal atoms per double-stranded molecule may account for the pharmacological activity of platinum based antitumor drugs. deoxyguanosine triphosphate Thiamine pyrophosphate carrier protein 1 Drosophila melanogaster
2 Although DmTpc1 has a low affinity for model [Pt(dien)(N7-5"-dGTP)] and cis-[Pt(NH3)2(py)(N7-5"-dGTP)] compared to dATP it"s well known that DNA platination level of few metal atoms per double-stranded molecule may account for the pharmacological activity of platinum based antitumor drugs. deoxyguanosine triphosphate Thiamine pyrophosphate carrier protein 1 Drosophila melanogaster