Title : Inhibition of glycogen synthase kinase-3β prevents remifentanil-induced hyperalgesia via regulating the expression and function of spinal N-methyl-D-aspartate receptors in vivo and vitro.

Pub. Date : 2013

PMID : 24147079






2 Functional Relationships(s)
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1 We found that remifentanil infusion at 1 mug kg(-1) min(-1) and 2 mug kg(-1) min(-1) caused mechanical and thermal hyperalgesia, up-regulated NMDA receptor subunits NR1 and NR2B expression in both membrane fraction and total lysate of the spinal cord dorsal horn and increased GSK-3beta activity in spinal cord dorsal horn. Remifentanil glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus
2 GSK-3beta inhibitor TDZD-8 significantly attenuated remifentanil-induced mechanical and thermal hyperalgesia from 2 h to 48 h after infusion, and this was associated with reversal of up-regulated NR1 and NR2B subunits in both membrane fraction and total lysate. Remifentanil glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus