Title : Behavioral and neurochemical pharmacology of six psychoactive substituted phenethylamines: mouse locomotion, rat drug discrimination and in vitro receptor and transporter binding and function.

Pub. Date : 2014 Mar

PMID : 24142203






3 Functional Relationships(s)
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1 Binding and functional activity of the phenethylamines at 5-HT1A, 5-HT2A, 5-HT2C receptors and monoamine transporters were assessed using cells heterologously expressing these proteins. Phenethylamines 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus
2 In 5-HT2A arachidonic acid release assays, the phenethylamines were partial to full agonists except 2C-I which was an antagonist. Phenethylamines 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus
3 Additionally, the substituted phenethylamines were full agonists at 5-HT2A and 5-HT2C receptors, but for 2C-T-2, this was not sufficient to produce hallucinogen-like discriminative stimulus effects. Phenethylamines 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus