Title : The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling.

Pub. Date : 2014 Feb

PMID : 24140598






1 Functional Relationships(s)
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1 We show that boswellic acid, a multitarget compound with potent anti-inflammatory action, exerts an anti-proliferative effect on HSCs, as in other cell models, by upregulating SHP-1 with subsequent dephosphorylation of PDGFR-beta and downregulation of PDGF-dependent signaling after PDGF stimulation. boswellic acid protein tyrosine phosphatase non-receptor type 6 Homo sapiens