Title : Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment.

Pub. Date : 2014 Jan

PMID : 24137007






2 Functional Relationships(s)
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1 In this report, we show that time-dependent kinetics of the NHEJ factors Ku80 and DNA-dependent protein kinase catalytic subunits (DNA-PKcs) in response to IR and bleomycin can be quantified by Number and Brightness analysis and Raster-scan Image Correlation Spectroscopy. Bleomycin X-ray repair cross complementing 5 Homo sapiens
2 Fluorescent-tagged Ku80 and DNA-PKcs quickly mobilized in response to IR and bleomycin treatments consistent with prior reports using laser-generated DSBs. Bleomycin X-ray repair cross complementing 5 Homo sapiens