Title : Association of plasma concentration of 4β-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl sulfate in stable kidney transplant recipients.

Pub. Date : 2014 Jan

PMID : 24135442






3 Functional Relationships(s)
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1 Association of plasma concentration of 4beta-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl sulfate in stable kidney transplant recipients. cholest-5-ene-3,4-diol cytochrome P450 family 3 subfamily A member 5 Homo sapiens
2 Plasma concentrations of 4beta-hydroxycholesterol were 57.1 +- 11.2, 42.1 +- 11.8, and 34.5 +- 7.3 ng/ml in recipients with CYP3A5*1/*1 (n = 5), *1/*3 (n = 15), and *3/*3 (n = 25) genotypes, respectively, with significant differences between three genotypes. cholest-5-ene-3,4-diol cytochrome P450 family 3 subfamily A member 5 Homo sapiens
3 Multiple regression analysis identified the number of CYP3A5*3 alleles in genotype, plasma concentration of 3-INDS, and body weight as independent variables associated with plasma concentration of 4beta-hydroxycholesterol. cholest-5-ene-3,4-diol cytochrome P450 family 3 subfamily A member 5 Homo sapiens