Title : P144, A TGF-β1 antagonist peptide, synergizes with sildenafil and enhances erectile response via amelioration of cavernosal fibrosis in diabetic rats.

Pub. Date : 2013 Dec

PMID : 24134744






1 Functional Relationships(s)
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1 AIMS: The aims of this study are to determine whether activation of TGF-beta1 and its downstream pathways is responsible for the reduced efficacy of the PDE5is in diabetic ED via abnormalities in cavernosal structures and to investigate the synergistic effects of the TGF-beta1 antagonist P144 and sildenafil on erectile response. Sildenafil Citrate transforming growth factor, beta 1 Rattus norvegicus