Title : Higher anti-tumour efficacy of platinum(IV) complex LA-12 is associated with its ability to bypass M-phase entry block induced in oxaliplatin-treated human colon cancer cells.

Pub. Date : 2013 Dec

PMID : 24118195






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 While oxaliplatin induced p53- and p21-dependent G2 -phase arrest associated with downregulation of cyclin B1 and Cdk1, LA-12 allowed cells to enter M-phase of the cell cycle regardless of p53/p21 status. Oxaliplatin tumor protein p53 Homo sapiens