Pub. Date : 2014 Nov
PMID : 24114993
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BK5.Akt(WT) transgenic mice, where Akt1 is overexpressed in basal epidermis, are highly sensitive to TPA-induced epidermal proliferation and two-stage skin carcinogenesis. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | BK5.Akt(WT) transgenic mice, where Akt1 is overexpressed in basal epidermis, are highly sensitive to TPA-induced epidermal proliferation and two-stage skin carcinogenesis. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Targeting mTORC1 with rapamycin effectively inhibited TPA-induced epidermal hyperplasia and hyperproliferation as well as tumor promotion in a dose-dependent manner in both wild-type and BK5.Akt(WT) mice. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | After 2 weeks of TPA treatment, LRCs had moved upward into the interfollicular epidermis from the bulge region of both wild-type and BK5.Akt(WT) mice. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |