Title : Conformational change of Sos-derived proline-rich peptide upon binding Grb2 N-terminal SH3 domain probed by NMR.

Pub. Date : 2013 Oct 9

PMID : 24105423






3 Functional Relationships(s)
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1 Conformational change of Sos-derived proline-rich peptide upon binding Grb2 N-terminal SH3 domain probed by NMR. Proline growth factor receptor bound protein 2 Homo sapiens
2 The N-terminal SH3 (nSH3) domain of Grb2 binds a proline-rich region present in the guanine nucleotide releasing factor, son of sevenless (Sos). Proline growth factor receptor bound protein 2 Homo sapiens
3 Using NMR relaxation dispersion and chemical shift analysis methods, we investigated the conformational change of the Sos-derived proline-rich peptide during the transition between the free and Grb2 nSH3-bound states. Proline growth factor receptor bound protein 2 Homo sapiens