Title : The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid.

Pub. Date : 2013 Aug

PMID : 24101387






1 Functional Relationships(s)
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1 NF-kappaB and MAPK cascades-activated transcription factor activator protein 1 (AP-1) and CREB-binding protein (CBP/p300) lead to expression of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (COX-2) and membrane-bound prostaglandin E synthase 1 (mPGES-1), and thus to increased release of arachidonic acid and production of prostaglandins, particularly prostaglandin E2 (PGE2). Arachidonic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens