Pub. Date : 2013 Dec
PMID : 24098980
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anti-cancer activity of anti-GLUT1 antibody-targeted polymeric micelles co-loaded with curcumin and doxorubicin. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 2 | METHODS: HCT-116 cells were treated with non-targeted and GLUT1-targeted CUR and DOX micelles as a single agent or in combination. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 3 | RESULTS: CUR + DOX-loaded micelles decorated with GLUT1 had a robust killing effect even at low doses of DOX in vitro. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 4 | RESULTS: CUR + DOX-loaded micelles decorated with GLUT1 had a robust killing effect even at low doses of DOX in vitro. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 5 | However, GLUT1-CUR and GLUT1-CUR + DOX micelles showed a significant tumor inhibition effect with an improvement in survival. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |
| 6 | Hence, we confirmed that GLUT1-CUR + DOX micelles are effective and deserve further investigation. | Doxorubicin | solute carrier family 2 member 1 | Homo sapiens |