Title : Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes.

Pub. Date : 2013 Dec

PMID : 24089376






10 Functional Relationships(s)
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1 Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes. Adenosine Triphosphate insulin Homo sapiens
2 Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes. Adenosine Triphosphate insulin Homo sapiens
3 It was reported that a concentration of insulin found in humans with insulin resistance inhibits low O2-induced ATP release. Adenosine Triphosphate insulin Homo sapiens
4 It was reported that a concentration of insulin found in humans with insulin resistance inhibits low O2-induced ATP release. Adenosine Triphosphate insulin Homo sapiens
5 Here, we investigate the hypothesis that C-peptide and insulin work synergistically to maintain low O2-induced ATP release from human erythrocytes. Adenosine Triphosphate insulin Homo sapiens
6 Here, we investigate the hypothesis that C-peptide and insulin work synergistically to maintain low O2-induced ATP release from human erythrocytes. Adenosine Triphosphate insulin Homo sapiens
7 Using a thin-film tonometer to alter O2 tension, we determined that either C-peptide or insulin alone inhibits low O2-induced ATP release in a concentration-dependent manner; however, coadministration of the peptides at a 1:1 ratio does not (n = 5; P < 0.05). Adenosine Triphosphate insulin Homo sapiens
8 Using a thin-film tonometer to alter O2 tension, we determined that either C-peptide or insulin alone inhibits low O2-induced ATP release in a concentration-dependent manner; however, coadministration of the peptides at a 1:1 ratio does not (n = 5; P < 0.05). Adenosine Triphosphate insulin Homo sapiens
9 However, at a concentration of insulin found in the peripheral circulation of humans under postprandial conditions (0.5 nM), a ratio of C-peptide to insulin of 6:1 inhibited low O2-induced ATP release (n = 5). Adenosine Triphosphate insulin Homo sapiens
10 However, at a concentration of insulin found in the peripheral circulation of humans under postprandial conditions (0.5 nM), a ratio of C-peptide to insulin of 6:1 inhibited low O2-induced ATP release (n = 5). Adenosine Triphosphate insulin Homo sapiens