Title : [Histamine release from human leukocytes after treatment with 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) and its structural analogs].

Pub. Date : 1985 Apr

PMID : 2408682






4 Functional Relationships(s)
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1 It was found that within the concentration range of 10(-10) to 10(-7) M PAF and its analogs induce a moderate histamine release from the leukocytes. Histamine PCNA clamp associated factor Homo sapiens
2 However, at higher concentrations (greater than 10(-7) M) PAF induces an enhanced release of histamine from the leukocytes of allergic patients as compared to healthy individuals. Histamine PCNA clamp associated factor Homo sapiens
3 PAF and its analogs significantly potentiate the allergens-induced release of histamine from the leukocytes of allergic patients. Histamine PCNA clamp associated factor Homo sapiens
4 It was assumed that PAF induces the expression or demasking of additional numbers of IgE receptors on the surface of basophils, which leads tot he stimulation of histamine release from the leukocytes in the presence of allergens. Histamine PCNA clamp associated factor Homo sapiens