Pub. Date : 2013
PMID : 24086693
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mutation Kv7.2 R463E increases phosphatidylinositol- 4,5-bisphosphate (PIP2) - channel interaction and diminished dramatically the inhibitory effect of tamoxifen compared with that for wild type Kv7.2. | Phosphatidylinositol 4,5-Diphosphate | potassium voltage-gated channel subfamily Q member 2 | Homo sapiens |
| 2 | The mutation Kv7.2 R463E increases phosphatidylinositol- 4,5-bisphosphate (PIP2) - channel interaction and diminished dramatically the inhibitory effect of tamoxifen compared with that for wild type Kv7.2. | Phosphatidylinositol 4,5-Diphosphate | potassium voltage-gated channel subfamily Q member 2 | Homo sapiens |
| 3 | Our results suggest that tamoxifen inhibited Kv7.2/Kv7.3 channels by interfering with PIP2-channel interaction because of its documented interaction with PIP2 and the similar effect of tamoxifen on various PIP2 sensitive channels. | Phosphatidylinositol 4,5-Diphosphate | potassium voltage-gated channel subfamily Q member 2 | Homo sapiens |