Title : G protein-dependent basal and evoked endothelial cell vWF secretion.

Pub. Date : 2014 Jan 16

PMID : 24081657






2 Functional Relationships(s)
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1 Using siRNA in cultured human umbilical vein ECs and human pulmonary artery ECs, depletion of Galpha12 and soluble N-ethylmaleimide-sensitive-fusion factor attachment protein alpha (alpha-SNAP), but not Galpha13, inhibited both basal and thrombin-induced vWF secretion, whereas overexpression of activated Galpha12 promoted vWF secretion. Ethylmaleimide von Willebrand factor Homo sapiens
2 Using siRNA in cultured human umbilical vein ECs and human pulmonary artery ECs, depletion of Galpha12 and soluble N-ethylmaleimide-sensitive-fusion factor attachment protein alpha (alpha-SNAP), but not Galpha13, inhibited both basal and thrombin-induced vWF secretion, whereas overexpression of activated Galpha12 promoted vWF secretion. Ethylmaleimide von Willebrand factor Homo sapiens