Title : GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration.

Pub. Date : 2013 Dec

PMID : 24080647






2 Functional Relationships(s)
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1 Moreover, they were active against darunavir (DRV)-resistant variants (EC50 in 0.03 to 0.034 muM range for GRL-04810 and 0.026 to 0.043 muM for GRL-05010), while DRV had EC50s between 0.02 and 0.174 muM. Darunavir nuclear receptor subfamily 3 group C member 1 Homo sapiens
2 Moreover, they were active against darunavir (DRV)-resistant variants (EC50 in 0.03 to 0.034 muM range for GRL-04810 and 0.026 to 0.043 muM for GRL-05010), while DRV had EC50s between 0.02 and 0.174 muM. Darunavir nuclear receptor subfamily 3 group C member 1 Homo sapiens