Title : Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats.

Pub. Date : 2013 Dec

PMID : 24080207






1 Functional Relationships(s)
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1 Tumors exposed to raloxifene, bexarotene and/or the combination showed significant suppression of proliferating cell nuclear antigen, cyclin D1, and beta-catenin with an increased apoptotic cells (3-fold) and p21 expression (3.8-fold) as compared tumors of rats fed control diet. Bexarotene proliferating cell nuclear antigen Rattus norvegicus