Title : Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling.

Pub. Date : 2013 Nov

PMID : 24072041






4 Functional Relationships(s)
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1 KEY MESSAGE: Glucosamine-mediated attenuation of TGF-beta signaling ameliorates renal fibrosis in vivo TGF-beta1-induced fibrogenic action is reduced by glucosamine in vitro N-glycosylation of the type II TGF-beta receptor is suppressed by glucosamine Glucosamine-induced defective N-glycosylation of TbetaRII decreases TGF-beta signaling. Glucosamine transforming growth factor beta 1 Homo sapiens
2 KEY MESSAGE: Glucosamine-mediated attenuation of TGF-beta signaling ameliorates renal fibrosis in vivo TGF-beta1-induced fibrogenic action is reduced by glucosamine in vitro N-glycosylation of the type II TGF-beta receptor is suppressed by glucosamine Glucosamine-induced defective N-glycosylation of TbetaRII decreases TGF-beta signaling. Glucosamine transforming growth factor beta 1 Homo sapiens
3 KEY MESSAGE: Glucosamine-mediated attenuation of TGF-beta signaling ameliorates renal fibrosis in vivo TGF-beta1-induced fibrogenic action is reduced by glucosamine in vitro N-glycosylation of the type II TGF-beta receptor is suppressed by glucosamine Glucosamine-induced defective N-glycosylation of TbetaRII decreases TGF-beta signaling. Glucosamine transforming growth factor beta 1 Homo sapiens
4 KEY MESSAGE: Glucosamine-mediated attenuation of TGF-beta signaling ameliorates renal fibrosis in vivo TGF-beta1-induced fibrogenic action is reduced by glucosamine in vitro N-glycosylation of the type II TGF-beta receptor is suppressed by glucosamine Glucosamine-induced defective N-glycosylation of TbetaRII decreases TGF-beta signaling. Glucosamine transforming growth factor beta 1 Homo sapiens