Title : 4-Nitrophenol induces Leydig cells hyperplasia, which may contribute to the differential modulation of the androgen receptor and estrogen receptor-α and -β expression in male rat testes.

Pub. Date : 2013 Nov 25

PMID : 24070737






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The existence of AR, ER-alpha and -beta in the testes suggests that estradiol and testosterone directly affect germ cells and that differential modulation of AR, ER-alpha and -beta in the testis may be involved in the direct effects of PNP or either the indirect effects of PNP-induced disruption of the estradiol-to-testosterone balance or the Leydig cells hyperplasia. Testosterone androgen receptor Rattus norvegicus
2 The existence of AR, ER-alpha and -beta in the testes suggests that estradiol and testosterone directly affect germ cells and that differential modulation of AR, ER-alpha and -beta in the testis may be involved in the direct effects of PNP or either the indirect effects of PNP-induced disruption of the estradiol-to-testosterone balance or the Leydig cells hyperplasia. Testosterone androgen receptor Rattus norvegicus