Title : Uptake, p53 pathway activation, and cytotoxic responses for Co(II) and Ni(II) in human lung cells: implications for carcinogenicity.

Pub. Date : 2013 Dec

PMID : 24068677






2 Functional Relationships(s)
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1 We found that Co(II) showed almost 8 times higher accumulation than Ni(II) in H460 cells but caused a less efficient activation of the transcriptional factor p53 as measured by its accumulation, Ser15 phosphorylation, and target gene expression. Nickel(2+) mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Co(II)-treated cells continued DNA replication at internal doses that caused massive apoptosis by Ni(II). Nickel(2+) mitochondrially encoded cytochrome c oxidase II Homo sapiens