Title : Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA.

Pub. Date : 2013 Oct 23

PMID : 24063363






1 Functional Relationships(s)
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1 Active DNA demethylation involves stepwise oxidation of mC to 5-hydroxymethylcytosine, 5-formylcytosine (fC), and potentially 5-carboxylcytosine (caC), excision of fC or caC by thymine DNA glycosylase (TDG), and restoration of cytosine via follow-on base excision repair. 5-carboxylcytosine thymine DNA glycosylase Homo sapiens