Pub. Date : 2013 Jul
PMID : 24046862
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using the NS398 specific inhibitor of COX-2, we provide evidence that reactive oxygen species by-produced by the COX-2 enzymatic activity are negligible in front of the total senescence-associated oxidative stress. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Using the NS398 specific inhibitor of COX-2, we provide evidence that reactive oxygen species by-produced by the COX-2 enzymatic activity are negligible in front of the total senescence-associated oxidative stress. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Taken together, these results suggest that COX-2 contributes to the establishment and maintenance of senescence of normal human fibroblasts via an independent-ROS and a dependent-PGE2/EPs intracrine pathway. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |