Title : Oxidative stress induces proliferation of colorectal cancer cells by inhibiting RUNX3 and activating the Akt signaling pathway.

Pub. Date : 2013 Nov

PMID : 24042352






3 Functional Relationships(s)
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1 Treatment of the cells with H2O2 also upregulated Akt mRNA and protein expression, and inhibited the binding of RUNX3 to the Akt promoter. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens
2 Treatment of the cells with H2O2 also upregulated Akt mRNA and protein expression, and inhibited the binding of RUNX3 to the Akt promoter. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens
3 The inverse correlation between the expression levels of RUNX3 and Akt in H2O2-treated cells was also associated with nuclear translocation of beta-catenin and upregulation of cyclin D1 expression, which induced cell proliferation. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens