Pub. Date : 2013
PMID : 24039733
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stimulation of osteoclast formation by RANKL requires interferon regulatory factor-4 and is inhibited by simvastatin in a mouse model of bone loss. | Simvastatin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 2 | We found that in vitro, IRF4 expression is upregulated during osteoclast differentiation induced by RANKL (receptor activator of nuclear factor-kappaB ligand), while simvastatin blocks RANKL-induced osteoclastogenesis and decreases expression of NFATc1 (nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1), IRF4 and osteoclast markers. | Simvastatin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 3 | To investigate the in vivo effects of simvastatin in RANKL-treated mice, we examined the bone mineral density (BMD) of a mouse model of bone loss, and found that simvastatin significantly reduced bone loss by suppressing osteoclast numbers in vivo, even in the presence of high concentrations of RANKL. | Simvastatin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 4 | To investigate the in vivo effects of simvastatin in RANKL-treated mice, we examined the bone mineral density (BMD) of a mouse model of bone loss, and found that simvastatin significantly reduced bone loss by suppressing osteoclast numbers in vivo, even in the presence of high concentrations of RANKL. | Simvastatin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |
| 5 | The results are consistent with the hypothesis that simvastatin blocks RANKL-induced IRF4 expression in osteoclastogenesis. | Simvastatin | tumor necrosis factor (ligand) superfamily, member 11 | Mus musculus |