Title : Inhibition of rat brain histamine-N-methyltransferase by 9-amino-1,2,3,4-tetrahydroacridine (THA).

Pub. Date : 1990 Sep 15

PMID : 2403387






1 Functional Relationships(s)
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1 THA was found to be a potent competitive inhibitor of rat brain HNMT in vitro, with a Ki of 35 nM with respect to both histamine and S-adenosyl-L-methionine, the co-substrate. Histamine histamine N-methyltransferase Rattus norvegicus