Title : Histone trimethylation of the p53 gene by expression of a constitutively active prolactin receptor in prostate cancer cells.

Pub. Date : 2013 Oct 31

PMID : 24032713






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Enhancer of zeste homologue 2 (EZH2), an important histone-modifying enzyme, is able to trimethylate histone 3 on lysine 27 (H3K27Me3), consequently leading to gene silencing, especially silencing of tumor suppressor genes such as p53. Lysine tumor protein p53 Homo sapiens