Title : Targeting of magnolin on ERKs inhibits Ras/ERKs/RSK2-signaling-mediated neoplastic cell transformation.

Pub. Date : 2014 Feb

PMID : 24031026






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, we found that magnolin, a compound found in the Magnolia species, directly targeted and inhibited ERK1 and ERK2 kinase activities with IC50 values of 87 and 16.5 nM by competing with adenosine triphosphate in an active pocket. Adenosine Triphosphate mitogen-activated protein kinase 3 Homo sapiens