Title : A proline-rich loop mediates specific functions of human sialidase NEU4 in SK-N-BE neuronal differentiation.

Pub. Date : 2013 Dec

PMID : 24030392






2 Functional Relationships(s)
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1 We have found that a proline-rich sequence of 81 amino acids, unique to NEU4 sequence, contains potential Akt and Erk1 kinase motifs. Proline AKT serine/threonine kinase 1 Homo sapiens
2 Our results demonstrate that the proline-rich region can also enhance cell proliferation and retinoic acid (RA)-induced neuronal differentiation and it is also involved in NEU4 interaction with Akt, as well as in substrate recognition, modifying directly or through the interaction with other protein(s) the enzyme specificity toward sialylated glycoprotein(s). Proline AKT serine/threonine kinase 1 Homo sapiens