Pub. Date : 2013
PMID : 24030317
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND/AIMS: Histamine remains the main mediator of allergic conjunctivitis and induces interleukin (IL)-6 and IL-8 production in human conjunctival epithelial cells (HCEC). | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | The purpose of the present study was to determine whether histamine induced IL-6 and IL-8 expression in HCEC, and to describe the relationship between human calcium-activated chloride channel (hCLCA) 1 activity and IL-6 and IL-8 expression. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | RESULTS: Histamine upregulated IL-6 and IL-8 expression and IL-6 and IL-8 secretion in a dose-dependent manner in HCEC. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | RESULTS: Histamine upregulated IL-6 and IL-8 expression and IL-6 and IL-8 secretion in a dose-dependent manner in HCEC. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | Niflumic acid (NFA), an hCLCA blocker, reduced histamine-induced IL-6 and IL-8 expression. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 6 | CONCLUSION: Histamine-induced IL-6 and IL-8 production could be attenuated by NFA, an hCLCA blocker. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |