Pub. Date : 2014 Apr
PMID : 24025724
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) decreased and Kelch-like erythroid cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) increased in the vehicle-treated group; however, these expressions were restored in the maxacalcitol- and insulin-treated groups. | maxacalcitol | Kelch-like ECH-associated protein 1 | Rattus norvegicus |
| 2 | CONCLUSIONS: It is suggested that maxacalcitol attenuates the progression of diabetic nephropathy by suppression of oxidative stress and amelioration of the Nrf2-Keap1 pathway in nonobese type 2 diabetes without significant changes in blood pressure and glomerular filtration rate. | maxacalcitol | Kelch-like ECH-associated protein 1 | Rattus norvegicus |