CPRiL

4 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	Upon Nrf2 activation glucose is preferentially metabolized through the pentose phosphate pathway with increased production of NADPH.	Pentosephosphates	NFE2 like bZIP transcription factor 2	Homo sapiens
2	Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1.	Pentosephosphates	NFE2 like bZIP transcription factor 2	Homo sapiens
3	Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1.	Pentosephosphates	NFE2 like bZIP transcription factor 2	Homo sapiens
4	We conclude that the Nrf2-dependent protection against oxidative stress relies on an intact pentose phosphate pathway and that there is crosstalk between metabolism and detoxification already at the level of gene expression in mammalian cells.	Pentosephosphates	NFE2 like bZIP transcription factor 2	Homo sapiens