Title : γH2AX foci formation in the absence of DNA damage: mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway.

Pub. Date : 2013 Nov 1

PMID : 24021642






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 gammaH2AX foci formation in the absence of DNA damage: mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway. gammah2ax checkpoint kinase 2 Homo sapiens
2 An increased level of gammaH2AX occurred in mitotic cells, and this increase was attenuated by DNA-PKcs inactivation or Chk2 depletion, but not by ATM inhibition. gammah2ax checkpoint kinase 2 Homo sapiens
3 The phosphorylation-mimic CHK2-T68D abrogated the attenuation of mitotic gammaH2AX induced by DNA-PKcs inactivation. gammah2ax checkpoint kinase 2 Homo sapiens