Pub. Date : 2013
PMID : 24009772
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin activated AMPK, down-regulated the unfolded protein response (UPR) demonstrated by significant decrease in the main UPR regulator GRP78, and led to UPR-mediated cell death via up-regulation of the ER stress/UPR cell death mediators IRE1alpha and CHOP. | Metformin | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | Using shRNA, we demonstrate that metformin-induced apoptosis is AMPK-dependent since AMPK knock-down rescued ALL cells, which correlated with down-regulation of IRE1alpha and CHOP and restoration of the UPR/GRP78 function. | Metformin | DNA damage inducible transcript 3 | Homo sapiens |