Title : Metformin Down-regulates TNF-α Secretion via Suppression of Scavenger Receptors in Macrophages.

Pub. Date : 2013 Aug

PMID : 24009539






1 Functional Relationships(s)
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1 Metformin reduced the production of NO, PGE2 and pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) through down-regulation of NF-kappaB translocation in macrophages in a dose-dependent manner. Metformin interleukin 1 beta Mus musculus