Pub. Date : 2013 Dec
PMID : 24005315
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency. | Vitamin D | insulin like growth factor 1 | Homo sapiens |
| 2 | OBJECTIVES: Previous studies suggested that vitamin D modulates circulating IGF1. | Vitamin D | insulin like growth factor 1 | Homo sapiens |
| 3 | The frequency of IGF1 values >=50th age- and sex-specific percentile in relation to vitamin D status, as determined by the concentration of 25-hydroxyvitamin D (25(OH)D), was retrospectively assessed in 69 GHD patients (57.4+-16.6 years) on stable hormone replacement and with 25(OH)D and IGF1 concurrently measured. | Vitamin D | insulin like growth factor 1 | Homo sapiens |
| 4 | Logistic regression with adjustment for recombinant human GH (rhGH) dose, vitamin D supplements, gender, use of thyroid hormones, corticosteroids or estrogen/testosterone, and season revealed a significant positive association between >=15 ng/ml 25(OH)D and IGF1 >=50th percentile (OR 4.4, 95% CI 1.0-18.8, P<0.05). | Vitamin D | insulin like growth factor 1 | Homo sapiens |
| 5 | CONCLUSIONS: Vitamin D increases circulating IGF1 in adults. | Vitamin D | insulin like growth factor 1 | Homo sapiens |
| 6 | As a result, a better vitamin D status may ease the achievement of normal IGF1 values in GHD. | Vitamin D | insulin like growth factor 1 | Homo sapiens |