Title : Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide Y (NPY) expression in the human SH-SY5Y neuroblastoma cell line.

Pub. Date : 2013 Sep 10

PMID : 23994577






3 Functional Relationships(s)
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Protein Name
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1 In addition, 12-O-tetradecanoylphorbol-13-acetate (TPA) known to differentiate SH-SY5Y cells into a neuronal phenotype and to increase NPY expression through activation of protein kinase C (PKC) was applied as a positive control (16nM). Tetradecanoylphorbol Acetate neuropeptide Y Homo sapiens
2 A further increase in expression was observed with simultaneous VPA and TPA treatment, suggesting that the two agents may increase NPY expression through different mechanisms. Tetradecanoylphorbol Acetate neuropeptide Y Homo sapiens
3 The increase in NPY mRNA by VPA and TPA was confirmed with qRT-PCR after 72h. Tetradecanoylphorbol Acetate neuropeptide Y Homo sapiens