Title : Sildenafil ameliorates biomarkers of genotoxicity in an experimental model of spontaneous atherosclerosis.

Pub. Date : 2013 Aug 28

PMID : 23981672






3 Functional Relationships(s)
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1 CONCLUSIONS: ApoE(-/-) mice chronically administered with sildenafil exhibited reduced levels of superoxide anion in MNC and less DNA fragmentation in MNC and liver cells, which are biomarkers of genotoxicity. Superoxides apolipoprotein E Mus musculus
2 RESULTS: MNC from apoE(-/-) vehicle exhibited a 2-fold increase in production of superoxide anion in comparison with WT. Superoxides apolipoprotein E Mus musculus
3 In contrast, sildenafil-administered apoE(-/-) mice showed superoxide anion levels similar to those observed in WT mice. Superoxides apolipoprotein E Mus musculus