Title : Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding.

Pub. Date : 2013 Sep 10

PMID : 23980182






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Huntington disease (HD) is a progressive neurodegenerative disorder caused by dominant polyglutamine (polyQ) expansion within the N terminus of huntingtin (Htt) protein. polyglutamine huntingtin Drosophila melanogaster
2 Huntington disease (HD) is a progressive neurodegenerative disorder caused by dominant polyglutamine (polyQ) expansion within the N terminus of huntingtin (Htt) protein. polyglutamine huntingtin Drosophila melanogaster
3 Huntington disease (HD) is a progressive neurodegenerative disorder caused by dominant polyglutamine (polyQ) expansion within the N terminus of huntingtin (Htt) protein. polyglutamine huntingtin Drosophila melanogaster
4 Huntington disease (HD) is a progressive neurodegenerative disorder caused by dominant polyglutamine (polyQ) expansion within the N terminus of huntingtin (Htt) protein. polyglutamine huntingtin Drosophila melanogaster
5 Strikingly, substitution of two potential copper-binding residues of Htt, Met8 and His82, completely dissociates the copper-intensifying toxicity of Htt exon1-polyQ. polyglutamine huntingtin Drosophila melanogaster
6 Strikingly, substitution of two potential copper-binding residues of Htt, Met8 and His82, completely dissociates the copper-intensifying toxicity of Htt exon1-polyQ. polyglutamine huntingtin Drosophila melanogaster