Title : The Nlrp3 inflammasome regulates acute graft-versus-host disease.

Pub. Date : 2013 Sep 23

PMID : 23980097






1 Functional Relationships(s)
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1 In this study, we show that, after conditioning therapy, intestinal commensal bacteria and the damage-associated molecular pattern uric acid contribute to Nlrp3 inflammasome-mediated IL-1beta production and that gastrointestinal decontamination and uric acid depletion reduced GvHD severity. Uric Acid interleukin 1 beta Mus musculus