Title : Does ascorbic acid protect against vanadium neurotoxicity in different regions of rat brain?

Pub. Date : 2002 Oct

PMID : 23978861






3 Functional Relationships(s)
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1 The objective of the study was to investigate protective effects of ascorbic acid on lipid peroxidative damage and perturbation of enzymes, glucose-6-phosphate dehydrogenase (G6PDH) and acetylcholinesterase (AChE) in discrete regions of rat brain after vanadium exposure. Vanadium acetylcholinesterase Rattus norvegicus
2 Interestingly, however, co-administration (L-ascorbic acid + vanadium) reversed the levels of ascorbic acid together with the activity of G6PDH and AChE towards normal values. Vanadium acetylcholinesterase Rattus norvegicus
3 CONCLUSION: These results suggested that vanadium neurotoxicity initiated lipid peroxidative damage and interferes with enzymes, G6PDH and AChE, in rat brain. Vanadium acetylcholinesterase Rattus norvegicus